Computeruser.com
Latest News

The Changing Role of Natural Products in Drug Discovery

NEW YORK July 19, 2011

The Changing Role of Natural Products in Drug Discovery

http://www.reportlinker.com/p0574968/The-Changing-Role-of-Natural-Products-in-Drug-Discovery.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Discovery_and_Development

Introduction

This report reveals how natural products have been of value to the pharmaceutical industry and yet how relatively little of their potential has been explored. It assesses strategies for exploring their continued potential and examines the therapeutic areas in which natural products may offer the greatest benefit. The report also profiles specialist companies.

Features and benefits

* Understand how small a fraction of natural products has been explored for pharmaceutical potential.

* Understand how natural products offer access to underexploited but biologically relevant regions of chemical space

* Identify in which therapeutic areas the exploration of natural products offers better prospects of success.

* Gain insight into the different approaches used for the exploitation of natural products and understand the influence of past successes and failures.

* Assess the value of specialist companies as possible partners or service providers.

Highlights

Natural products have been the source of most classes of antibacterial drugs, a field where target-driven medicinal chemistry programs have proved highly unsuccessful. Natural products have also been the source of, or inspiration for, the majority of older anticancer drugs.

Natural products often have highly novel, albeit complex, chemical structures that have evolved to support biological activity. They thus represent potentially valuable chemical leads in the development of drugs.

Very large numbers of microbial strains and marine natural products have yet to be identified, or explored for their potential therapeutic utility. Nonetheless, the sole pursuit of the development of natural products as therapeutic agents is a risky strategy for a company.

Your key questions answered

* How do natural products offer value in the development of new drugs?

* Who could provide a useful partner in trying to exploit natural product resources?

* What therapeutic areas offer better prospects for commercially exploiting natural product derived therapeutics?

* How do natural products offer scope for innovation in developing new drugs?

* What are the potential problems in trying to exploit natural products?

Executive Summary

Introduction

Use of natural products in drug discovery

Exploiting natural resources

Corporate strategies

Case histories

Specialist companies

Future outlook

About the author

Disclaimer

Introduction

Summary

Introduction

Folk medicine

Use of natural products

From extracts to pure chemicals

Use of natural products in drug discovery

Summary

Overview

Pharmacological tools

Chemical leads

Marketed therapeutics

Infectious diseases

Cancer

Inflammatory disease

Cardiovascular disease

Metabolic diseases

CNS disease

Recent approvals

Exploiting natural resources

Summary

Introduction

Chemical entities

Biosynthetic pathways

Accessing novel chemical space

Disadvantages

Biological sources

Botanical resources

Microbiological resources

Marine resources

Corporate strategies

Summary

Introduction

Exclusive access to natural resources

Prospecting for natural products

Evaluating natural products

Drawing from traditional medicines

Natural products as the sole corporate focus

Case histories

Summary

Introduction

Aspirin

?-Lactam antibiotics

Taxanes

Epothilones

Discodermolide

Eribulin

Artemisinin

Specialist companies

Summary

Introduction

Biotica Technology

EntreChem Biotechnology

GW Pharma

Hypha Discovery

Magellan BioScience

MerLion Pharmaceuticals

Nereus Pharmaceuticals

PharmaMar

Phynova

Phytopharm

PhytoPharmacon

PhytoQuest

Defunct companies

CalBioMarine Technologies

Cerylid Biosciences

Calyx Therapeutics

Shaman Pharmaceutical

Summary of compounds in development

Summary of natural product screening collections

The role of academia

Future outlook

Summary

Introduction

Continued role for natural products

Licensing opportunities

Key opportunities

Oncology

Infectious diseases

Assessment

Appendix

Glossary/Abbreviations

Bibliography

To order this report:

Drug Discovery and Development Industry : The Changing Role of Natural Products in Drug Discovery

Drug Discovery and Development Business News

Market Research Report

Company Profile, SWOT and Revenue Analysis!

[email protected]

SOURCE Reportlinker

Leave a comment

seks shop - izolasyon
basic theory test book basic theory test